Arthritis Research and Therapy
Geisel School of Medicine
Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express
Fairhurst, AM., Connolly, J.E., Hintz, K.A. et al. Regulation and localization of endogenous human tristetraprolin. Arthritis Res Ther 5, R214 (2003). https://doi.org/10.1186/ar778
Dartmouth Digital Commons Citation
Fairhurst, Anna-Marie; Connolly, John E.; Hintz, Katharine A; and Goulding, Nicolas J, "Regulation and Localization of Endogenous Human Tristetraprolin" (2003). Dartmouth Scholarship. 523.