Arthritis Research and Therapy
Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express
Fairhurst, Anna-Marie; Connolly, John E.; Hintz, Katharine A; and Goulding, Nicolas J, "Regulation and Localization of Endogenous Human Tristetraprolin" (2003). Open Dartmouth: Faculty Open Access Articles. 523.