Arthritis Research and Therapy
Geisel School of Medicine
In Sjögren's syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular surface. We investigated the effect of blockade of the lymphotoxin-beta receptor (LTBR) pathway on lacrimal-gland pathology in the NOD mouse model of Sjögren's syndrome.
Fava RA, Kennedy SM, Wood SG, Bolstad AI, Bienkowska J, Papandile A, Kelly JA, Mavragani CP, Gatumu M, Skarstein K, Browning JL. Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome. Arthritis Res Ther. 2011;13(6):R182. doi: 10.1186/ar3507. Epub 2011 Nov 1. PMID: 22044682; PMCID: PMC3334628.
Dartmouth Digital Commons Citation
Fava, Roy A.; Kennedy, Susan M.; Wood, Sheryl G.; Bolstad, Anne I.; Bienkowska, Jadwiga; Papandile, Adrian; and Kelly, John A., "Lymphotoxin-Beta Receptor Blockade Reduces CXCL13 in Lacrimal Glands and Improves Corneal Integrity in the NOD Model of Sjögren's Syndrome" (2011). Dartmouth Scholarship. 533.