Geisel School of Medicine
Department of Biological Sciences
The fidelity of DNA replication serves as the nidus for both genetic evolution and genomic instability fostering disease. Single nucleotide polymorphisms (SNPs) constitute greater than 80% of the genetic variation between individuals. A new theory regarding DNA replication fidelity has emerged in which selectivity is governed by base-pair geometry through interactions between the selected nucleotide, the complementary strand, and the polymerase active site. We hypothesize that specific nucleotide combinations in the flanking regions of SNP fragments are associated with mutation.
Arehart E, Gleim S, White B, Hwa J, Moore JH. Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms. BioData Min. 2009 Mar 30;2(1):2. doi: 10.1186/1756-0381-2-2. PMID: 19331672; PMCID: PMC2669078.
Dartmouth Digital Commons Citation
Arehart, Eric; Gleim, Scott; White, Bill; Hwa, John; and Moore, Jason H., "Multifactor Dimensionality Reduction Analysis Identifies Specific Nucleotide Patterns Promoting Genetic Polymorphisms" (2009). Dartmouth Scholarship. 551.