Document Type
Article
Publication Date
3-30-2009
Publication Title
BioData Mining
Department
Geisel School of Medicine
Additional Department
Department of Biological Sciences
Abstract
The fidelity of DNA replication serves as the nidus for both genetic evolution and genomic instability fostering disease. Single nucleotide polymorphisms (SNPs) constitute greater than 80% of the genetic variation between individuals. A new theory regarding DNA replication fidelity has emerged in which selectivity is governed by base-pair geometry through interactions between the selected nucleotide, the complementary strand, and the polymerase active site. We hypothesize that specific nucleotide combinations in the flanking regions of SNP fragments are associated with mutation.
DOI
10.1186/1756-0381-2-2
Original Citation
Arehart E, Gleim S, White B, Hwa J, Moore JH. Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms. BioData Min. 2009 Mar 30;2(1):2. doi: 10.1186/1756-0381-2-2. PMID: 19331672; PMCID: PMC2669078.
Dartmouth Digital Commons Citation
Arehart, Eric; Gleim, Scott; White, Bill; Hwa, John; and Moore, Jason H., "Multifactor Dimensionality Reduction Analysis Identifies Specific Nucleotide Patterns Promoting Genetic Polymorphisms" (2009). Dartmouth Scholarship. 551.
https://digitalcommons.dartmouth.edu/facoa/551
Included in
Bioinformatics Commons, Biology Commons, Computational Biology Commons, Genetics Commons