Title
The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading
Document Type
Article
Publication Date
10-21-2014
Publication Title
Biotechnology for Biofuels
Department
Thayer School of Engineering
Abstract
BackgroundClostridium thermocellum is a model thermophilic organism for the production of biofuels from lignocellulosic substrates. The majority of publications studying the physiology of this organism use substrate concentrations of ≤10 g/L. However, industrially relevant concentrations of substrate start at 100 g/L carbohydrate, which corresponds to approximately 150 g/L solids. To gain insight into the physiology of fermentation of high substrate concentrations, we studied the growth on, and utilization of high concentrations of crystalline cellulose varying from 50 to 100 g/L by C. thermocellum. .
DOI
10.1186/s13068-014-0155-1
Dartmouth Digital Commons Citation
Holwerda, Evert K.; Thorne, Philip G.; Olson, Daniel G.; Amador-Noguez, Daniel; Engle, Nancy L.; Tschaplinski, Timothy J.; van Dijken, Johannes P.; and Lynd, Lee R., "The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading" (2014). Dartmouth Scholarship. 561.
https://digitalcommons.dartmouth.edu/facoa/561