Document Type

Article

Publication Date

11-10-2015

Publication Title

BioMed Central Cancer

Abstract

USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model for this disease.

DOI

10.1186/s12885-015-1883-8

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