BioMed Central Cancer
USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model for this disease.
Chinyengetere, Fadzai; Sekula, David J.; Lu, Yun; Giustini, Andrew J.; Sanglikar, Aarti; Kawakami, Masanori; and Ma, Tian, "Mice Null for the Deubiquitinase USP18 Spontaneously Develop Leiomyosarcomas" (2015). Open Dartmouth: Faculty Open Access Articles. 576.