BioMed Central Cancer
The Mre11/Rad50/Nbs1 (MRN) complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could be used to target therapy to tumors with these defects. The goal of this study was to identify these defects in the NCI60 panel of cell lines and identify compounds that might elicit selective cytotoxicity.
Garner, Kristen M. K. and Eastman, Alan, "Variations in Mre11/Rad50/Nbs1 Status and DNA Damage-Induced S-Phase Arrest in the Cell Lines of the NCI60 Panel" (2011). Open Dartmouth: Faculty Open Access Articles. 579.