BioMed Central Cancer
Testicular germ cell tumors (TGCTs) are classified as seminonas or non-seminomas of which a major subset is embryonal carcinoma (EC) that can differentiate into diverse tissues. The pluripotent nature of human ECs resembles that of embryonic stem (ES) cells. Many Wnt signalling species are regulated during differentiation of TGCT-derived EC cells. This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency.
Snow, Grace E.; Kasper, Allison C.; Busch, Alexander M.; Schwarz, Elisabeth; Ewings, Katherine E.; Bee, Thomas; Spinella, Michael J.; Dmitrovsky, Ethan; and Freemantle, Sarah J., "Wnt Pathway Reprogramming During Human Embryonal Carcinoma Differentiation and Potential for Therapeutic Targeting" (2009). Open Dartmouth: Faculty Open Access Articles. 580.