Document Type
Article
Publication Date
10-29-2009
Publication Title
BioMed Central Cancer
Department
Geisel School of Medicine
Abstract
Testicular germ cell tumors (TGCTs) are classified as seminonas or non-seminomas of which a major subset is embryonal carcinoma (EC) that can differentiate into diverse tissues. The pluripotent nature of human ECs resembles that of embryonic stem (ES) cells. Many Wnt signalling species are regulated during differentiation of TGCT-derived EC cells. This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency.
DOI
10.1186/1471-2407-9-383
Original Citation
Snow GE, Kasper AC, Busch AM, Schwarz E, Ewings KE, Bee T, Spinella MJ, Dmitrovsky E, Freemantle SJ. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. BMC Cancer. 2009 Oct 29;9:383. doi: 10.1186/1471-2407-9-383. PMID: 19874621; PMCID: PMC2777936.
Dartmouth Digital Commons Citation
Snow, Grace E.; Kasper, Allison C.; Busch, Alexander M.; Schwarz, Elisabeth; Ewings, Katherine E.; Bee, Thomas; Spinella, Michael J.; Dmitrovsky, Ethan; and Freemantle, Sarah J., "Wnt Pathway Reprogramming During Human Embryonal Carcinoma Differentiation and Potential for Therapeutic Targeting" (2009). Dartmouth Scholarship. 580.
https://digitalcommons.dartmouth.edu/facoa/580
Included in
Cancer Biology Commons, Oncology Commons, Therapeutics Commons