BioMed Central Gastroenterology
Geisel School of Medicine
Toxoplasma gondii, an obligate intracellular parasite, can invade intestinal epithelial cells and elicit a robust Th1 immune response. In this model of intestinal inflammation, CD8+ intraepithelial lymphocytes (IELs) secrete transforming growth factor (TGF)-β, which appears necessary for the maintenance of homeostasis in the intestine. However, the mechanism responsible for the IEL migration to the inflamed intestine is still unclear.An in vitro coculture cell system was used to quantify the IEL attraction by an infected intestinal epithelial cell line (m-ICcl2). We used CCR5-deficient mice to determine which chemokine receptor—chemokine interaction could be responsible for the recruitment of antigen-specific CD8+ IELs to the small intestine for the promotion of parasite clearance and host recovery.
Luangsay S, Kasper LH, Rachinel N, Minns LA, Mennechet FJ, Vandewalle A, Buzoni-Gatel D. CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells. Gastroenterology. 2003 Aug;125(2):491-500. doi: 10.1016/s0016-5085(03)00903-x. PMID: 12891552.
Dartmouth Digital Commons Citation
Luangsay, Souphalone; Kasper, Lloyd H.; Rachinel, Nicolas; and Minns, Laurie A., "CCR5 Mediates Specific Migration of Toxoplasma Gondii—Primed CD8+ Lymphocytes to Inflammatory Intestinal Epithelial Cells" (2003). Dartmouth Scholarship. 593.