BioMed Central Medical Genomics
Genome-wide interrogation of DNA methylation (DNAm) in blood-derived leukocytes has become feasible with the advent of CpG genotyping arrays. In epithelial ovarian cancer (EOC), one report found substantial DNAm differences between cases and controls; however, many of these disease-associated CpGs were attributed to differences in white blood cell type distributions. We examined blood-based DNAm in 336 EOC cases and 398 controls; we included only high-quality CpG loci that did not show evidence of association with white blood cell type distributions to evaluate association with case status and overall survival.
Fridley, Brooke L.; Armasu, Sebastian M.; Cicek, Mine S.; Larson, Melissa C.; Wang, Chen; Winham, Stacey J.; Kalli, Kimberly R.; and Koestler, Devin C., "Methylation of Leukocyte DNA and Ovarian Cancer: Relationships with Disease Status and Outcome" (2014). Open Dartmouth: Faculty Open Access Articles. 637.