Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dysregulation of the microvasculature and with organ failure in clinical severe sepsis.
Doerschug, Kevin C.; Delsing, Angela S.; Schmidt, Gregory A.; and Ashare, Alix, "Renin-Angiotensin System Activation Correlates with Microvascular Dysfunction in a Prospective Cohort Study of Clinical Sepsis" (2010). Open Dartmouth: Faculty Open Access Articles. 721.