Document Type
Article
Publication Date
2-22-2010
Publication Title
Critical Care
Department
Geisel School of Medicine
Abstract
Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dysregulation of the microvasculature and with organ failure in clinical severe sepsis.
DOI
10.1186/cc8887
Original Citation
Doerschug KC, Delsing AS, Schmidt GA, Ashare A. Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis. Crit Care. 2010;14(1):R24. doi: 10.1186/cc8887. Epub 2010 Feb 22. PMID: 20175923; PMCID: PMC2875539.
Dartmouth Digital Commons Citation
Doerschug, Kevin C.; Delsing, Angela S.; Schmidt, Gregory A.; and Ashare, Alix, "Renin-Angiotensin System Activation Correlates with Microvascular Dysfunction in a Prospective Cohort Study of Clinical Sepsis" (2010). Dartmouth Scholarship. 721.
https://digitalcommons.dartmouth.edu/facoa/721