3 Genes of the Map Kinase Cascade, MEK-2, MPK-1/SUR-1 and LET-60 RAS, Are Required for Meiotic Cell-Cycle Progression in Caenorhabditis-Elegans

D. L. Church
K. L. Guan
E J. Lambie

D L Church;K L Guan;E J Lambie


In the germline of Caenorhabditis elegans hermaphrodites, meiotic cell cycle progression occurs in spatially restricted regions, Immediately after leaving the distal mitotic region, germ cells enter meiosis and thereafter remain in the pachytene stage of first meiotic prophase for an extended period, At the dorsoventral gonadal flexure, germ cells exit pachytene and subsequently become arrested in diakinesis, We have found that exit from pachytene is dependent on the function of three members of