BCL-2 Protein Expression is Widespread in the Developing Nervous-System and Retained in the Adult PNS

D. E. Merry
D. J. Veis
W F. Hickey
S J. Korsmeyer

D E Merry;D J Veis;W F Hickey;S J Korsmeyer


Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene has been shown to protect a variety of cell types from programmed cell death. We have examined the distribution of bcl-2 protein in the developing and adult nervous systems. bcl-2 protein is widespread during embryonic development. Proliferating neuroepithelial cells of ventricular zones as well as the postmitotic cells of the cortical plate, cerebellum, hippocampus and spinal cord express bcl-2. Po