BCL-2 Protein Expression is Widespread in the Developing Nervous-System and Retained in the Adult PNS
D E Merry;D J Veis;W F Hickey;S J Korsmeyer
Abstract
Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene has been shown to protect a variety of cell types from programmed cell death. We have examined the distribution of bcl-2 protein in the developing and adult nervous systems. bcl-2 protein is widespread during embryonic development. Proliferating neuroepithelial cells of ventricular zones as well as the postmitotic cells of the cortical plate, cerebellum, hippocampus and spinal cord express bcl-2. Po
This paper has been withdrawn.