LAG-2 may Encode a Signaling Ligand for the GLP-1 and LIN-12 Receptors of C-Elegans

Samuel T. Henderson
Dali Gao
Eric J. Lambie
Judith Kimble

Henderson, Samuel T;Gao, Dali;Lambie, Eric J;Kimble, Judith


The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the receptors ALP-1 and LIN-12. In this paper, we report that Lag-2 encodes a putative membrane protein with sequence similarity to Drosophila Delta, a proposed ligand for the Notch receptor. Furthermore, we show that the Lag-2 promoter drives expression of a reporter protein in the signaling distal tip cell (DTC) of the DTC/germline interaction. By in situ hybridization, we have found that endogenous lag-2 mRN