Infection and Immunity
Geisel School of Medicine
Chronic airway infection is a hallmark of cystic fibrosis (CF) and many CF patients are infected persistently by Staphylococcus aureus. Thymidine-dependent trimethoprim-sulfamethoxazole (SXT)-resistant S. aureus small-colony variants (SCVs), often in combination with isogenic normal S. aureus phenotypes, are highly prevalent and persistent in airway secretions of CF patients due to long-term SXT therapy (B. Kahl, M. Herrmann, A. S. Everding, H. G. Koch, K. Becker, E. Harms, R. A. Proctor, and G.
Kahl BC, Belling G, Becker P, Chatterjee I, Wardecki K, Hilgert K, Cheung AL, Peters G, Herrmann M. Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles. Infect Immun. 2005 Jul;73(7):4119-26. doi: 10.1128/IAI.73.7.4119-4126.2005. PMID: 15972501; PMCID: PMC1168585.
Dartmouth Digital Commons Citation
Kahl, Barbara C.; Belling, Gunnar; Becker, Petra; Chatterjee, Indranil; Wardecki, Katrin; Hilgert, Karin; and Cheung, Ambrose, "Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles" (2005). Dartmouth Scholarship. 950.