Infection and Immunity
Geisel School of Medicine
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 2005 Jan;73(1):617-21. doi: 10.1128/IAI.73.1.617-621.2005. PMID: 15618203; PMCID: PMC538931.
Dartmouth Digital Commons Citation
Kelly, Michelle N.; Kolls, Jay K.; Happel, Kyle; and Schwartzman, Joseph D., "Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection" (2005). Dartmouth Scholarship. 953.