Infection and Immunity
The expression of virulence determinants in Staphylococcus aureus is controlled by global regulatory loci (e.g., sar and agr). The sar locus is composed of three overlapping transcripts (sar P1, P3, and P2 transcripts from P1, P3, and P2 promoters, respectively), all encoding the 372-bp sarA gene. The level of SarA, the major regulatory protein, is partially controlled by the differential activation of sar promoters. We previously partially purified a ∼12 kDa protein with a DNA-specific column
Manna, Adhar and Cheung, Ambrose L., "Characterization of sarR, a Modulator of sar Expression in Staphylococcus aureus" (2001). Open Dartmouth: Faculty Open Access Articles. 969.