Infection and Immunity
Geisel School of Medicine
The relative contributions of toxin-coregulated pilus (TCP) and cell-associated mannose-sensitive hemagglutinin (MSHA) to the colonization ability of Vibrio cholerae O1 El Tor biotype strains and O139 Bengal strains was determined by using isogenic parental and in-frame deletion mutant pairs in the infant mouse cholera model. Both the El Tor and O139 tcpA mutant strains showed a dramatic defect in colonization as indicated by their competitive indices, whereas deletion of mshA had a negligible effect on colonization in either background.
Thelin KH, Taylor RK. Toxin-coregulated pilus, but not mannose-sensitive hemagglutinin, is required for colonization by Vibrio cholerae O1 El Tor biotype and O139 strains. Infect Immun. 1996;64(7):2853-2856. doi:10.1128/IAI.64.7.2853-2856.1996
Dartmouth Digital Commons Citation
Thelin, K Helene and Taylor, Ronald K., "Toxin-coregulated Pilus, but Not Mannose-sensitive Hemagglutinin, is Required for Colonization by Vibrio Cholerae O1 El Tor Biotype and O139 Strains." (1996). Open Dartmouth: Published works by Dartmouth faculty. 996.