Infection and Immunity
The relative contributions of toxin-coregulated pilus (TCP) and cell-associated mannose-sensitive hemagglutinin (MSHA) to the colonization ability of Vibrio cholerae O1 El Tor biotype strains and O139 Bengal strains was determined by using isogenic parental and in-frame deletion mutant pairs in the infant mouse cholera model. Both the El Tor and O139 tcpA mutant strains showed a dramatic defect in colonization as indicated by their competitive indices, whereas deletion of mshA had a negligible effect on colonization in either background.
Thelin, K Helene and Taylor, Ronald K., "Toxin-coregulated Pilus, but Not Mannose-sensitive Hemagglutinin, is Required for Colonization by Vibrio Cholerae O1 El Tor Biotype and O139 Strains." (1996). Open Dartmouth: Faculty Open Access Scholarship. 996.