Download

Download Poster (4.5 MB)

Student Class

2029

Student Affiliation

WISP Intern

First Advisor

Irene Georgakoudi

First Advisor Department

Department of Engineering Sciences—Thayer School of Engineering

Abstract

Using a combined two-photon excitation fluorescence (TPEF) and second-harmonic generation (SHG) approach, our research seeks to further the quantification of skin components in a quest toward diagnostic tools with higher accuracy and reduced invasiveness for patients. Images are taken both ex vivo and in vivo, of healthy and malignant tissues, with a 600 × 600 micron field of view. We demonstrate how computational analysis can effectively exploit signals emitted by skin to provide diagnostic insight.

Publication Date

Spring 5-27-2026

Keywords

Precision Optical Diagnostics, Pixel-level, two-photon excitation fluorescence, second-harmonic generation, non-invasive

Disciplines

Diagnosis | Investigative Techniques

Original Citation

Gerogiannis, A., & Saint James, C. (2026, May 27). Pixel-level fiber stratification: Quantitative imaging analysis of pigmented lesion morphology. Karen E. Wetterhahn Science Symposium, Dartmouth College, Hanover, NH.

Pixel-Level Fiber Stratification: Quantitative Imaging Analysis of Pigmented Lesion Morphology

Share

COinS