Document Type

Article

Publication Date

3-4-2011

Publication Title

Journal of Bacteriology

Department

Geisel School of Medicine

Abstract

Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.

DOI

10.1128/JB.00027-11

Original Citation

Nair D, Memmi G, Hernandez D, Bard J, Beaume M, Gill S, Francois P, Cheung AL. Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. J Bacteriol. 2011 May;193(9):2332-5. doi: 10.1128/JB.00027-11. Epub 2011 Mar 4. PMID: 21378186; PMCID: PMC3133102.

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