Document Type

Article

Publication Date

2004

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

DOI

10.1128/JVI.78.11.6055-6060.2004

Original Citation

Green KA, Ahonen CL, Cook WJ, Green WR. CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency. J Virol. 2004 Jun;78(11):6055-60. doi: 10.1128/JVI.78.11.6055-6060.2004. PMID: 15141004; PMCID: PMC415804.

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