Document Type
Article
Publication Date
2004
Publication Title
Journal of Virology
Department
Geisel School of Medicine
Abstract
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
DOI
10.1128/JVI.78.11.6055-6060.2004
Original Citation
Green KA, Ahonen CL, Cook WJ, Green WR. CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency. J Virol. 2004 Jun;78(11):6055-60. doi: 10.1128/JVI.78.11.6055-6060.2004. PMID: 15141004; PMCID: PMC415804.
Dartmouth Digital Commons Citation
Green, Kathy A.; Ahonen, Cory L.; Cook, W. James; and Green, William R., "CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency" (2004). Dartmouth Scholarship. 1307.
https://digitalcommons.dartmouth.edu/facoa/1307
