Document Type

Article

Publication Date

7-28-2006

Publication Title

PLoS Computational Biology

Department

Geisel School of Medicine

Abstract

The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.

DOI

10.1371/journal.pcbi.0020096

Original Citation

Mehra A, Hong CI, Shi M, Loros JJ, Dunlap JC, Ruoff P. Circadian rhythmicity by autocatalysis. PLoS Comput Biol. 2006 Jul 28;2(7):e96. doi: 10.1371/journal.pcbi.0020096. Epub 2006 Jun 8. PMID: 16863394; PMCID: PMC1523307.

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