Document Type
Article
Publication Date
10-2011
Publication Title
PloS One
Department
Geisel School of Medicine
Abstract
Background: We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens. We also showed that persistence of these CD8 T cells is supported, in an antigen-dependent fashion, by concurrent autoimmune melanocyte destruction. Herein we explore the requirement of CD4 T cell help in priming and maintaining this protective CD8 T cell response to melanoma.
DOI
10.1371/journal.pone.0026491
Original Citation
Côté AL, Byrne KT, Steinberg SM, Zhang P, Turk MJ. Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help. PLoS One. 2011;6(10):e26491. doi: 10.1371/journal.pone.0026491. Epub 2011 Oct 26. PMID: 22046294; PMCID: PMC3202545.
Dartmouth Digital Commons Citation
Côté, Anik L.; Byrne, Katelyn T.; Steinberg, Shannon M.; Zhang, Peisheng; and Turk, Mary Jo, "Protective CD8 Memory T Cell Responses to Mouse Melanoma Are Generated in the Absence of CD4 T Cell Help" (2011). Dartmouth Scholarship. 1536.
https://digitalcommons.dartmouth.edu/facoa/1536