Document Type

Article

Publication Date

10-2011

Publication Title

PloS One

Department

Geisel School of Medicine

Abstract

Background: We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens. We also showed that persistence of these CD8 T cells is supported, in an antigen-dependent fashion, by concurrent autoimmune melanocyte destruction. Herein we explore the requirement of CD4 T cell help in priming and maintaining this protective CD8 T cell response to melanoma.

DOI

10.1371/journal.pone.0026491

Original Citation

Côté AL, Byrne KT, Steinberg SM, Zhang P, Turk MJ. Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help. PLoS One. 2011;6(10):e26491. doi: 10.1371/journal.pone.0026491. Epub 2011 Oct 26. PMID: 22046294; PMCID: PMC3202545.

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