Document Type

Article

Publication Date

12-10-2015

Publication Title

PLoS Neglected Tropical Diseases

Department

Geisel School of Medicine

Abstract

Background: Hypoxic microenvironments are generated during fungal infection. It has been described that to survive in the human host, fungi must also tolerate and overcome in vivo microenvironmental stress conditions including low oxygen tension; however nothing is known how Paracoccidioides species respond to hypoxia. The genus Paracoccidioides comprises human thermal dimorphic fungi and are causative agents of paracoccidioidomycosis (PCM), an important mycosis in Latin America.

DOI

10.1371/journal.pntd.0004282

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