Document Type

Article

Publication Date

12-20-2016

Publication Title

PloS One

Department

Geisel School of Medicine

Abstract

The development of a novel tuberculosis vaccine is a leading global health priority. SRL172, an inactivated, whole-cell mycobacterial vaccine, was safe, immunogenic and reduced the incidence of culture-confirmed tuberculosis in a phase III trial in HIV-infected and BCG immunized adults in Tanzania. Here we describe the immunogenicity and protective efficacy of DAR-901, a booster vaccine against tuberculosis manufactured from the same seed strain using a new scalable method.

DOI

10.1371/journal.pone.0168521

Share

COinS