Document Type
Article
Publication Date
12-20-2016
Publication Title
PloS One
Department
Geisel School of Medicine
Abstract
The development of a novel tuberculosis vaccine is a leading global health priority. SRL172, an inactivated, whole-cell mycobacterial vaccine, was safe, immunogenic and reduced the incidence of culture-confirmed tuberculosis in a phase III trial in HIV-infected and BCG immunized adults in Tanzania. Here we describe the immunogenicity and protective efficacy of DAR-901, a booster vaccine against tuberculosis manufactured from the same seed strain using a new scalable method.
DOI
10.1371/journal.pone.0168521
Dartmouth Digital Commons Citation
Lahey, Timothy; Laddy, Dominick; Hill, Krystal; and Schaeffer, Jacqueline, "Immunogenicity and Protective Efficacy of the DAR-901 Booster Vaccine in a Murine Model of Tuberculosis" (2016). Dartmouth Scholarship. 1700.
https://digitalcommons.dartmouth.edu/facoa/1700