Document Type

Article

Publication Date

2011

Publication Title

Antimicrobial Agents and Chemotherapy

Department

Geisel School of Medicine

Abstract

Previous articles reported that beta-lactam antibiotics increase the expression of Staphylococcus aureus Panton-Valentine leukocidin (PVL) by activating its transcription. We investigated the mechanisms underlying the inductor effect of beta-lactams on PVL expression by determining targets and regulatory pathways possibly implicated in this process. We measured PVL production in the presence of oxacillin (nonselective), imipenem (penicillin-binding protein 1 [PBP1] selective), cefotaxime (PBP2 s

DOI

10.1128/AAC.01401-10

Original Citation

Dumitrescu O, Choudhury P, Boisset S, Badiou C, Bes M, Benito Y, Wolz C, Vandenesch F, Etienne J, Cheung AL, Bowden MG, Lina G. Beta-lactams interfering with PBP1 induce Panton-Valentine leukocidin expression by triggering sarA and rot global regulators of Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul;55(7):3261-71. doi: 10.1128/AAC.01401-10. Epub 2011 Apr 18. PMID: 21502633; PMCID: PMC3122422.

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