Document Type
Article
Publication Date
2011
Publication Title
Antimicrobial Agents and Chemotherapy
Department
Geisel School of Medicine
Abstract
Previous articles reported that beta-lactam antibiotics increase the expression of Staphylococcus aureus Panton-Valentine leukocidin (PVL) by activating its transcription. We investigated the mechanisms underlying the inductor effect of beta-lactams on PVL expression by determining targets and regulatory pathways possibly implicated in this process. We measured PVL production in the presence of oxacillin (nonselective), imipenem (penicillin-binding protein 1 [PBP1] selective), cefotaxime (PBP2 s
DOI
10.1128/AAC.01401-10
Original Citation
Dumitrescu O, Choudhury P, Boisset S, Badiou C, Bes M, Benito Y, Wolz C, Vandenesch F, Etienne J, Cheung AL, Bowden MG, Lina G. Beta-lactams interfering with PBP1 induce Panton-Valentine leukocidin expression by triggering sarA and rot global regulators of Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul;55(7):3261-71. doi: 10.1128/AAC.01401-10. Epub 2011 Apr 18. PMID: 21502633; PMCID: PMC3122422.
Dartmouth Digital Commons Citation
Dumitrescu, Oana; Choudhury, Priya; Boisset, Sandrine; Badiou, Cedric; Bes, Michele; Benito, Yvonne; Wolz, Christiane; Vandenesch, Francois; Etienne, Jerome; and Cheung, Ambrose L., "β-Lactams Interfering with PBP1 Induce Panton-Valentine Leukocidin Expression by Triggering sarA and rot Global Regulators of Staphylococcus aureus" (2011). Dartmouth Scholarship. 470.
https://digitalcommons.dartmouth.edu/facoa/470
