Document Type

Article

Publication Date

7-2005

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

Chronic airway infection is a hallmark of cystic fibrosis (CF) and many CF patients are infected persistently by Staphylococcus aureus. Thymidine-dependent trimethoprim-sulfamethoxazole (SXT)-resistant S. aureus small-colony variants (SCVs), often in combination with isogenic normal S. aureus phenotypes, are highly prevalent and persistent in airway secretions of CF patients due to long-term SXT therapy (B. Kahl, M. Herrmann, A. S. Everding, H. G. Koch, K. Becker, E. Harms, R. A. Proctor, and G.

DOI

10.1128/IAI.73.7.4119-4126.2005

Original Citation

Kahl BC, Belling G, Becker P, Chatterjee I, Wardecki K, Hilgert K, Cheung AL, Peters G, Herrmann M. Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles. Infect Immun. 2005 Jul;73(7):4119-26. doi: 10.1128/IAI.73.7.4119-4126.2005. PMID: 15972501; PMCID: PMC1168585.

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