Document Type
Article
Publication Date
7-2005
Publication Title
Infection and Immunity
Department
Geisel School of Medicine
Abstract
Chronic airway infection is a hallmark of cystic fibrosis (CF) and many CF patients are infected persistently by Staphylococcus aureus. Thymidine-dependent trimethoprim-sulfamethoxazole (SXT)-resistant S. aureus small-colony variants (SCVs), often in combination with isogenic normal S. aureus phenotypes, are highly prevalent and persistent in airway secretions of CF patients due to long-term SXT therapy (B. Kahl, M. Herrmann, A. S. Everding, H. G. Koch, K. Becker, E. Harms, R. A. Proctor, and G.
DOI
10.1128/IAI.73.7.4119-4126.2005
Original Citation
Kahl BC, Belling G, Becker P, Chatterjee I, Wardecki K, Hilgert K, Cheung AL, Peters G, Herrmann M. Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles. Infect Immun. 2005 Jul;73(7):4119-26. doi: 10.1128/IAI.73.7.4119-4126.2005. PMID: 15972501; PMCID: PMC1168585.
Dartmouth Digital Commons Citation
Kahl, Barbara C.; Belling, Gunnar; Becker, Petra; Chatterjee, Indranil; Wardecki, Katrin; Hilgert, Karin; and Cheung, Ambrose, "Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles" (2005). Dartmouth Scholarship. 950.
https://digitalcommons.dartmouth.edu/facoa/950