Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles

Authors

Barbara C. Kahl, University of Muenster
Gunnar Belling, University of Muenster
Petra Becker, University of Muenster
Indranil Chatterjee, University of Saarland
Katrin Wardecki, University of Muenster
Karin Hilgert, University of Saarland
Ambrose Cheung, Dartmouth CollegeFollow

Document Type

Article

Publication Date

7-2005

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

Chronic airway infection is a hallmark of cystic fibrosis (CF) and many CF patients are infected persistently by Staphylococcus aureus. Thymidine-dependent trimethoprim-sulfamethoxazole (SXT)-resistant S. aureus small-colony variants (SCVs), often in combination with isogenic normal S. aureus phenotypes, are highly prevalent and persistent in airway secretions of CF patients due to long-term SXT therapy (B. Kahl, M. Herrmann, A. S. Everding, H. G. Koch, K. Becker, E. Harms, R. A. Proctor, and G.

DOI

10.1128/IAI.73.7.4119-4126.2005

Original Citation

Kahl BC, Belling G, Becker P, Chatterjee I, Wardecki K, Hilgert K, Cheung AL, Peters G, Herrmann M. Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles. Infect Immun. 2005 Jul;73(7):4119-26. doi: 10.1128/IAI.73.7.4119-4126.2005. PMID: 15972501; PMCID: PMC1168585.

Dartmouth Digital Commons Citation

Kahl, Barbara C.; Belling, Gunnar; Becker, Petra; Chatterjee, Indranil; Wardecki, Katrin; Hilgert, Karin; and Cheung, Ambrose, "Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles" (2005). Dartmouth Scholarship. 950.
https://digitalcommons.dartmouth.edu/facoa/950