Document Type

Article

Publication Date

12-24-2007

Publication Title

Journal of Bacteriology

Department

Geisel School of Medicine

Abstract

The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

DOI

10.1128/JB.01826-07

Original Citation

Cheung AL, Nishina K, Manna AC. SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression. J Bacteriol. 2008 Mar;190(6):2239-43. doi: 10.1128/JB.01826-07. Epub 2008 Jan 4. PMID: 18178734; PMCID: PMC2258893.

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