The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules

Authors

Kathy A. Green, Dartmouth CollegeFollow
W. James Cook, Dartmouth CollegeFollow
Arlene H. Sharpe, Brigham and Women’s Hospital
William R. Green, Dartmouth CollegeFollow

Document Type

Article

Publication Date

11-2002

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40^−/− and CD154^−/− B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4⁺ T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86^−/− B6 mice develop MAIDS after LP-BM5 infection.

DOI

10.1128/JVI.76.24.13106-13110.2002

Dartmouth Digital Commons Citation

Green, Kathy A.; Cook, W. James; Sharpe, Arlene H.; and Green, William R., "The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules" (2002). Dartmouth Scholarship. 1126.
https://digitalcommons.dartmouth.edu/facoa/1126