Title
Short-lived and Long-lived Bone Marrow Plasma Cells Are Derived from a Novel Precursor Population
Document Type
Article
Publication Date
3-18-2002
Publication Title
The Journal of Experimental Medicine
Department
Geisel School of Medicine
Abstract
The contribution that long-lived bone marrow (BM) plasma cells (PCs) provide to enduring humoral immunity has been underscored by a number of recent studies. However, little is known about the immediate precursors that give rise to long-lived PCs in the BM of immune individuals. We have identified subsets of antigen-experienced B cells within the immune BM that are precursors to PCs. These PC precursors arise in the BM 14 days after immunization and persist for greater than 9 months. Phenotypically distinct subsets of PC precursors give rise to short-lived or long-lived PCs. The differentiation of PC precursors to PCs occurs in the absence of antigen and requires cell division. The functional significance of these newly identified PC precursors in the persistence and quality of the humoral immune response is discussed.
DOI
10.1084/jem.20011626
Original Citation
O'Connor BP, Cascalho M, Noelle RJ. Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population. J Exp Med. 2002;195(6):737-745. doi:10.1084/jem.20011626
Dartmouth Digital Commons Citation
O'Connor, Brian P.; Cascalho, Marilia; and Noelle, Randolph J., "Short-lived and Long-lived Bone Marrow Plasma Cells Are Derived from a Novel Precursor Population" (2002). Dartmouth Scholarship. 1153.
https://digitalcommons.dartmouth.edu/facoa/1153