Document Type
Article
Publication Date
7-18-2005
Publication Title
The Journal of Experimental Medicine
Department
Geisel School of Medicine
Abstract
Fetal survival during gestation implies that tolerance mechanisms suppress the maternal immune response to paternally inherited alloantigens. Here we show that the inhibitory T cell costimulatory molecule, programmed death ligand 1 (PDL1), has an important role in conferring fetomaternal tolerance in an allogeneic pregnancy model. Blockade of PDL1 signaling during murine pregnancy resulted in increased rejection rates of allogeneic concepti but not syngeneic concepti. Fetal rejection was T cell
DOI
10.1084/jem.20050019
Original Citation
Guleria I, Khosroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH. A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med. 2005 Jul 18;202(2):231-7. doi: 10.1084/jem.20050019. PMID: 16027236; PMCID: PMC2213002.
Dartmouth Digital Commons Citation
Guleria, Indira; Khosroshahi, Arezou; Ansari, Mohammed Javeed; Habicht, Antje; Azuma, Miyuki; Yagita, Hideo; and Noelle, Randolph J., "A Critical Role for the Programmed Death Ligand 1 in Fetomaternal Tolerance" (2005). Dartmouth Scholarship. 1157.
https://digitalcommons.dartmouth.edu/facoa/1157