Acute Pancreatitis Accelerates Initiation and Progression to Pancreatic Cancer in Mice Expressing Oncogenic Kras in the Nestin Cell Lineage
Document Type
Article
Publication Date
11-28-2011
Publication Title
PLOS One
Department
Geisel School of Medicine
Abstract
Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia (PanIN) between 2 and 4 months. The mice die around 6 month-old of unrelated causes, and it is therefore not possible to assess whether the lesions will progress to carcinoma. We now report that two brief episodes of caerulein-induced acute pancreatitis in 2 month-old mice causes rapid PanIN progression and pancreatic ductal adenocarcinoma (PDAC) development by 4 months of age. These events occur with similar frequency as observed in animals where the oncogene is targeted during embryogenesis to all pancreatic cell types. Thus, these data show that oncogenic Kras-driven PanIN originating in a non-ductal compartment can rapidly progress to PDAC when subjected to a brief inflammatory insult.
DOI
10.1371/journal.pone.0027725
Original Citation
Carrière C, Young AL, Gunn JR, Longnecker DS, Korc M. Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage. PLoS One. 2011;6(11):e27725. doi: 10.1371/journal.pone.0027725. Epub 2011 Nov 28. PMID: 22140463; PMCID: PMC3225359.
Dartmouth Digital Commons Citation
Carriere, Catherine; Young, Alison L.; Gunn, Jason R.; Longnecker, Daniel S.; and Korc, Murray, "Acute Pancreatitis Accelerates Initiation and Progression to Pancreatic Cancer in Mice Expressing Oncogenic Kras in the Nestin Cell Lineage" (2011). Dartmouth Scholarship. 116.
https://digitalcommons.dartmouth.edu/facoa/116
