Cytolytic T Lymphocytes Specific for Tumors and Infected Cells from Mice with a Retrovirus-induced Immunodeficiency Syndrome.

Authors

Jennifer G. Erbe, Dartmouth College
Kathy A. Green, Dartmouth CollegeFollow
Karen M. Crassi, Dartmouth CollegeFollow
Herbert C. Morse, National Institute of Allergy and Infectious Diseases
W R. Green, Dartmouth College

Document Type

Article

Publication Date

5-1992

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.

Original Citation

Erbe JG, Green KA, Crassi KM, Morse HC 3rd, Green WR. Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome. J Virol. 1992;66(5):3251-3256. doi:10.1128/JVI.66.5.3251-3256.1992

Dartmouth Digital Commons Citation

Erbe, Jennifer G.; Green, Kathy A.; Crassi, Karen M.; Morse, Herbert C.; and Green, W R., "Cytolytic T Lymphocytes Specific for Tumors and Infected Cells from Mice with a Retrovirus-induced Immunodeficiency Syndrome." (1992). Dartmouth Scholarship. 1174.
https://digitalcommons.dartmouth.edu/facoa/1174