Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection

Authors

Michael Molloy, Dartmouth College
Weijun Zhang, Dartmouth College
Edward Usherwood, Dartmouth College

Document Type

Article

Publication Date

8-4-2010

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8⁺ T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8⁺ T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8⁺ T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8⁺ T cell mononucleosis.

DOI

10.1128/JVI.00856-10

Original Citation

Molloy M, Zhang W, Usherwood E. Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection. J Virol. 2010 Oct;84(20):10923-7. doi: 10.1128/JVI.00856-10. Epub 2010 Aug 4. PMID: 20686022; PMCID: PMC2950560.

Dartmouth Digital Commons Citation

Molloy, Michael; Zhang, Weijun; and Usherwood, Edward, "Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection" (2010). Dartmouth Scholarship. 1201.
https://digitalcommons.dartmouth.edu/facoa/1201