MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation

Authors

Ching-Yi Tsai, Dartmouth College
S. Rameeza Allie, Dartmouth College
Weijun Zhang, Dartmouth College
Edward J. Usherwood, Dartmouth College

Document Type

Article

Publication Date

12-5-2012

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.

DOI

10.1128/JVI.01742-12

Dartmouth Digital Commons Citation

Tsai, Ching-Yi; Allie, S. Rameeza; Zhang, Weijun; and Usherwood, Edward J., "MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation" (2012). Dartmouth Scholarship. 1254.
https://digitalcommons.dartmouth.edu/facoa/1254