Document Type
Article
Publication Date
1-1991
Publication Title
Molecular and Cellular Biology
Department
Geisel School of Medicine
Abstract
Although an extensive number of biological processes are under the daily control of the circadian biological clock, little is known about how the clock maintains its regulatory networks within a cell. An important aspect of this temporal control is the daily control of gene expression. Previously we identified two morning-specific genes that are regulated by the clock through daily control of gene expression (J. Loros, S. Denome, and J.C. Dunlap, Science 243:385-388, 1989). We have now introduced a method for transcriptional analysis in Neurospora crassa and used this nuclear run-on procedure to show that regulation of mRNA abundance for these two morning-specific genes occurs at the level of transcription. This transcriptional regulation by the circadian clock provides a basis for isolating circadian rhythm mutants.
Original Citation
Loros JJ, Dunlap JC. Neurospora crassa clock-controlled genes are regulated at the level of transcription. Mol Cell Biol. 1991;11(1):558-563. doi:10.1128/mcb.11.1.558
Dartmouth Digital Commons Citation
Loros, Jennifer J. and Dunlap, Jay C., "Neurospora Crassa Clock-Controlled Genes are Regulated at the Level of Transcription." (1991). Dartmouth Scholarship. 1265.
https://digitalcommons.dartmouth.edu/facoa/1265
Included in
Genetic Processes Commons, Medical Biochemistry Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons
