Document Type
Article
Publication Date
1-16-2009
Publication Title
Cellular Physiology and Biochemistry
Department
Geisel School of Medicine
Abstract
P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to test the hypothesis that Corr4a and VRT325, investigational compounds that increase ΔF508-CFTR mediated Cl− secretion in human CF airway cells, reduce the pro-inflammatory response to P. aeruginosa.
DOI
10.1159/000204108
Dartmouth Digital Commons Citation
Talebian, Laleh; Coutermarsh, Bonita; Channon, Jacqueline Y.; and Stanton, Bruce A., "Corr4A and VRT325 do not Reduce the Inflammatory Response to P. aeruginosa in Human Cystic Fibrosis Airway Epithelial Cells" (2009). Dartmouth Scholarship. 1285.
https://digitalcommons.dartmouth.edu/facoa/1285
Included in
Medical Immunology Commons, Medical Microbiology Commons, Medical Physiology Commons, Respiratory Tract Diseases Commons