Corr4A and VRT325 do not Reduce the Inflammatory Response to P. aeruginosa in Human Cystic Fibrosis Airway Epithelial Cells

Authors

Laleh Talebian, Dartmouth College
Bonita Coutermarsh, Dartmouth CollegeFollow
Jacqueline Y. Channon, Dartmouth College
Bruce A. Stanton, Dartmouth College

Document Type

Article

Publication Date

1-16-2009

Publication Title

Cellular Physiology and Biochemistry

Department

Geisel School of Medicine

Abstract

P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to test the hypothesis that Corr4a and VRT325, investigational compounds that increase ΔF508-CFTR mediated Cl⁻ secretion in human CF airway cells, reduce the pro-inflammatory response to P. aeruginosa.

DOI

10.1159/000204108

Dartmouth Digital Commons Citation

Talebian, Laleh; Coutermarsh, Bonita; Channon, Jacqueline Y.; and Stanton, Bruce A., "Corr4A and VRT325 do not Reduce the Inflammatory Response to P. aeruginosa in Human Cystic Fibrosis Airway Epithelial Cells" (2009). Dartmouth Scholarship. 1285.
https://digitalcommons.dartmouth.edu/facoa/1285