Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus

Authors

Kathy A. Green, Dartmouth CollegeFollow
Li Wang, Dartmouth College
Randolph J. Noelle, Dartmouth College
William R. Green, Dartmouth CollegeFollow

Document Type

Article

Publication Date

7-8-2015

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

Inhibition of T-cell responses in tumor microenvironments by myeloid-derived suppressor cells (MDSCs) is widely accepted. We demonstrated augmentation of monocytic MDSCs whose suppression of not only T-cell, but also B-cell, responsiveness paralleled the immunodeficiency during LP-BM5 retrovirus infection. MDSCs inhibited T cells by inducible nitric oxide synthase (iNOS)/nitric oxide (NO), but uniquely, inhibition of B cells was ~50% dependent each on iNOS/NO and the MDSC-expressed negative-checkpoint regulator VISTA. Blockade with a combination of iNOS/NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell responsiveness.

DOI

10.1128/JVI.00888-15

Dartmouth Digital Commons Citation

Green, Kathy A.; Wang, Li; Noelle, Randolph J.; and Green, William R., "Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus" (2015). Dartmouth Scholarship. 1333.
https://digitalcommons.dartmouth.edu/facoa/1333