T-Cell Responses to the M3 Immune Evasion Protein of Murid Gammaherpesvirus 68 Are Partially Protective and Induced with Lytic Antigen Kinetics

Authors

Joshua J. Obar, Dartmouth College
Douglas C. Donovan, Dartmouth College
Sarah G. Crist, Dartmouth CollegeFollow
Ondine Silvia, University of Edinburgh
James P. Stewart, University of Edinburgh
Edward J. Usherwood, Dartmouth College

Document Type

Article

Publication Date

10-2004

Publication Title

Journal of Virology

Department

Geisel School of Medicine

Abstract

DNA vaccination with the M3 gene, encoding an immune evasion molecule expressed during both the acute lytic and persistent phases of murid gammaherpesvirus 68 infection, yielded a significantly lower titer of virus in the lung than controls. The protection seen was dependent on T cells, and we mapped an epitope recognized by CD8 T cells. The immune response to this epitope follows the same kinetics as lytic cycle antigens, despite the fact that this gene is expressed in both lytic and persistent stages of infection. This has important implications for our understanding of T-cell responses to putative latency-associated gammaherpesvirus proteins and how vaccination may improve control of these viruses.

DOI

10.1128/JVI.78.19.10829-10832.2004

Original Citation

Obar JJ, Donovan DC, Crist SG, Silvia O, Stewart JP, Usherwood EJ. T-cell responses to the M3 immune evasion protein of murid gammaherpesvirus 68 are partially protective and induced with lytic antigen kinetics. J Virol. 2004 Oct;78(19):10829-32. doi: 10.1128/JVI.78.19.10829-10832.2004. PMID: 15367651; PMCID: PMC516430.

Dartmouth Digital Commons Citation

Obar, Joshua J.; Donovan, Douglas C.; Crist, Sarah G.; Silvia, Ondine; Stewart, James P.; and Usherwood, Edward J., "T-Cell Responses to the M3 Immune Evasion Protein of Murid Gammaherpesvirus 68 Are Partially Protective and Induced with Lytic Antigen Kinetics" (2004). Dartmouth Scholarship. 1366.
https://digitalcommons.dartmouth.edu/facoa/1366