Document Type
Article
Publication Date
10-19-2017
Publication Title
Journal of Virology
Department
Geisel School of Medicine
Abstract
Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.
DOI
10.1128/JVI.01200-16
Original Citation
Enquist LW, Leib DA. Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses. J Virol. 2016 Dec 16;91(1):e01200-16. doi: 10.1128/JVI.01200-16. PMID: 27795407; PMCID: PMC5165195.
Dartmouth Digital Commons Citation
Enquist, Lynn and Leib, David A., "Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses" (2017). Dartmouth Scholarship. 1367.
https://digitalcommons.dartmouth.edu/facoa/1367
Included in
Medical Immunology Commons, Virology Commons, Virus Diseases Commons
