Document Type
Article
Publication Date
3-1994
Publication Title
Journal of Bacteriology
Department
Department of Biological Sciences
Abstract
Bradyrhizobium japonicum produces delta-aminolevulinic acid, the universal precursor of tetrapyrroles, in a reaction catalyzed by the product of the hemA gene. Expression of the B. japonicum hemA gene is affected by iron availability. Activity of a hemA-lacZ fusion is increased approximately threefold by iron, and RNA analysis indicates that iron regulation is at the level of mRNA accumulation. To our knowledge, this is the first example of an iron-regulated heme biosynthetic gene in prokaryotes.
DOI
10.1128/jb.176.5.1535-1538.1994
Original Citation
Page KM, Connolly EL, Guerinot ML. Effect of iron availability on expression of the Bradyrhizobium japonicum hemA gene. J Bacteriol. 1994;176(5):1535-1538. doi:10.1128/jb.176.5.1535-1538.1994
Dartmouth Digital Commons Citation
Page, Karen M.; Connolly, Erin; and Guerinot, Mary Lou, "Effect of Iron Availability on Expression of the Bradyrhizobium Japonicum hemA Gene." (1994). Dartmouth Scholarship. 1437.
https://digitalcommons.dartmouth.edu/facoa/1437