Document Type
Article
Publication Date
8-2012
Publication Title
PLoS Genetics
Department
Geisel School of Medicine
Abstract
The eukaryotic nucleus is both spatially and functionally partitioned. This organization contributes to the maintenance, expression, and transmission of genetic information. Though our ability to probe the physical structure of the genome within the nucleus has improved substantially in recent years, relatively little is known about the factors that regulate its organization or the mechanisms through which specific organizational states are achieved. Here, we show that Drosophila melanogaster Condensin II induces axial compaction of interphase chromosomes, globally disrupts interchromosomal interactions, and promotes the dispersal of peri-centric heterochromatin. These Condensin II activities compartmentalize the nucleus into discrete chromosome territories and indicate commonalities in the mechanisms that regulate the spatial structure of the genome during mitosis and interphase.
DOI
10.1371/journal.pgen.1002873
Dartmouth Digital Commons Citation
Bauer, Christopher R. R.; Hartl, Tom A.; and Bosco, Giovanni, "Condensin II Promotes the Formation of Chromosome Territories by Inducing Axial Compaction of Polyploid Interphase Chromosomes" (2012). Dartmouth Scholarship. 1556.
https://digitalcommons.dartmouth.edu/facoa/1556
