Document Type
Article
Publication Date
12-2012
Publication Title
PLoS Computational Biology
Department
Geisel School of Medicine
Abstract
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.
DOI
10.1371/journal.pcbi.1002822
Original Citation
Bush WS, Moore JH. Chapter 11: Genome-wide association studies. PLoS Comput Biol. 2012;8(12):e1002822. doi: 10.1371/journal.pcbi.1002822. Epub 2012 Dec 27. PMID: 23300413; PMCID: PMC3531285.
Dartmouth Digital Commons Citation
Bush, William S. and Moore, Jason H., "Chapter 11: Genome-Wide Association Studies" (2012). Dartmouth Scholarship. 1566.
https://digitalcommons.dartmouth.edu/facoa/1566
