Elevated MTSS1 Expression Associated with Metastasis and Poor Prognosis of Residual Hepatitis B-Related Hepatocellular Carcinoma

Authors

Xiu-Yan Huang, Shangha i Jiaotong University
Zi-Li Huang, Xuhui Central Hospital
Bin Xu, The Tenth People's Hospital of Tongji University
Zi Chen, Dartmouth CollegeFollow

Document Type

Article

Publication Date

5-26-2016

Publication Title

Journal of Experimental & Clinical Cancer Research

Department

Thayer School of Engineering

Abstract

Background: Hepatectomy generally offers the best chance of long-term survival for patients with hepatocellular carcinoma (HCC). Many studies have shown that hepatectomy accelerates tumor metastasis, but the mechanism remains unclear.

Methods: An orthotopic nude mice model with palliative HCC hepatectomy was performed in this study. Metastasis-related genes in tumor following resection were screened; HCC invasion, metastasis, and some molecular alterations were examined in vivo and in vitro. Clinical significance of key gene mRNA expression was also analyzed.

DOI

10.1186/s13046-016-0361-8

Dartmouth Digital Commons Citation

Huang, Xiu-Yan; Huang, Zi-Li; Xu, Bin; and Chen, Zi, "Elevated MTSS1 Expression Associated with Metastasis and Poor Prognosis of Residual Hepatitis B-Related Hepatocellular Carcinoma" (2016). Dartmouth Scholarship. 1675.
https://digitalcommons.dartmouth.edu/facoa/1675