Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses
Nikhil Khankari;Xiao-Ou Shu;Wanqing Wen;Peter Kraft;Sara Lindström;Ulrike Peters;Joellen Schildkraut;Fredrick Schumacher;Paolo Bofetta;Angela Risch;Heike Bickeböller;Christopher Amos;Douglas Easton;Rosalind Eeles;Stephen Gruber;Christopher Haiman;David Hunter;Stephen Chanock;Brandon Pierce;Wei Zheng;on behalf of the Colorectal Transdisciplinary Study (CORECT);Discovery;Biology;and Risk of Inherited Variants in Breast Cancer (DRIVE);Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE);Transdisciplinary Research in Cancer of the Lung (TRICL)
Abstract
Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers.