Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

Nikhil Khankari
Xiao-Ou Shu
Wanqing Wen
Peter Kraft

Nikhil Khankari;Xiao-Ou Shu;Wanqing Wen;Peter Kraft;Sara Lindström;Ulrike Peters;Joellen Schildkraut;Fredrick Schumacher;Paolo Bofetta;Angela Risch;Heike Bickeböller;Christopher Amos;Douglas Easton;Rosalind Eeles;Stephen Gruber;Christopher Haiman;David Hunter;Stephen Chanock;Brandon Pierce;Wei Zheng;on behalf of the Colorectal Transdisciplinary Study (CORECT);Discovery;Biology;and Risk of Inherited Variants in Breast Cancer (DRIVE);Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE);Transdisciplinary Research in Cancer of the Lung (TRICL)


Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers.